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Author

Jia-Hao Guo

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2 papers indexed here

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Open access Sep 2026

TRIM46 drives lung adenocarcinoma progression by stabilizing PRDX1 via SUMOylation

Lung adenocarcinoma (LUAD) is one of the major subtypes of non-small cell lung cancer (NSCLC), but the molecular mechanisms underlying LUAD initiation and progression remain incompletely understood. In the present study, we identified TRIM46 as a key driver of LUAD progression. TRIM46 is significantly overexpressed i...

Shao-Kun Yu, Xiao Ke, Zhi-Li Liu et al. · 0 citations
Sep 2026

SCRMP-mediated SUMOylation of CSNK2B facilitates DNA damage repair to promote cisplatin resistance in small cell lung cancer.

Small cell lung cancer (SCLC) represents the most lethal subtype of lung carcinoma. Platinum-based agents, such as cisplatin and carboplatin, remain the cornerstone of first-line therapy for patients with SCLC, whether administered as chemotherapy alone or in combination with immunotherapy. However, patients frequently...

Yu-Li Chen, Qin-Nan Chen, Jia-Hao Guo et al. · 0 citations

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