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Open access Sep 2026

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

ABSTRACT Sepsis‐induced acute lung injury (ALI) is a lethal inflammatory condition with limited therapeutic options. Macrophage autophagic homeostasis is essential to constrain septic ALI inflammation, though its upstream regulation remains elusive. Here, we report that lysosomal‐associated protein transmembrane 5 (LAP...

Lang Jiang, Qi-Lan Li, Hao Liu et al. · 0 citations
Review Open access Jul 2026

Cardiac regeneration and repair: the emerging mechanisms and therapeutic approaches

This review provides a historical and biologically grounded synthesis of preclinical advances in cardiac repair, regeneration and cardiomyocyte reprogramming, with particular emphasis on translational feasibility and clinical applicability.

Yi-Long Li, Kexiao Zheng, Yinghua Liu et al. · 0 citations
Review Open access Aug 2026

Regulatory T cells in cardiac allograft vasculopathy: from mechanistic insights to clinical tolerance

Cardiac allograft vasculopathy (CAV) is the primary impairment that influences the long-term prognosis of transplanted hearts. CAV is characterized by diffuse intimal hyperplasia of the coronary arteries, which is mediated by chronic inflammation, the alloimmune response, and vascular remodeling. Current immunosuppress...

Buyan Li, Yu-Ling Su, Yanglin Hao et al. · 0 citations

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