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Jia-Hui Li

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Open access Aug 2026

Gram-scale microbial synthesis of hypericin, a low-abundance complex phytochemical drug candidate

This work re-engineer the polyketide biosynthetic pathways in Cladosporium fulvum and overcome substrate inhibition and metabolic inefficiency, achieving scalable and plant-pathway-independent biomanufacturing of hypericin.

Qing-Juan Cui, Xin Shi, Jia-Hui Li et al. · 0 citations

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