Review
Open access
Oct 2026
The role of linker histone H1.2 in tumor progression, resistance, and clinical translation.
Linker histone H1 has traditionally been regarded as a structural scaffold that stabilizes higher-order chromatin organization. Recent evidence, however, indicates that H1 variants are dynamic chromatin regulators with variant-specific functions in cancer. Among them, H1.2, encoded by H1-2 (formerly HIST1H1C), has emer...
Jia-Yang Zhou, Jia-Jian Shi, Ling Zheng et al.
· Epigenomics · 0 citations