Oct 2026
Analysis of the influence of rs1801265 polymorphism on DPD enzyme activity and contributing factors in the Chinese population.
INTRODUCTION Dihydropyrimidine dehydrogenase (DPD), encoded by DPYD, is essential for 5-fluorouracil (5-FU) metabolism, yet functional variants remain understudied in Chinese populations. METHODS We enrolled 300 healthy Chinese subjects and measured DPD activity as the HPLC-based 5-FU degradation rate in PBMCs. Five...
Lin-Kun Pan, Yang Shen, Hai-Bo Jiang et al.
· Pharmacogenomics (London) · 0 citations