Generalizable single-cell perturbation response prediction using energy-guided flow matching
Predicting phenotypic and transcriptional responses to perturbations at single-cell resolution provides a powerful tool for probing biological systems. However, existing methods typically rely on fixed mappings learned during training, making it challenging to calibrate distribution shifts or adapt to novel perturbatio...
Jia-Nan Wei, Jia-Jun Hong, Gui-Kun Chen et al.
· 0 citations