Biomimetic electroactive nano-heterojunction for vascularized bone regeneration in large segmental load-bearing bone defects via temporal regulation of endogenous functional ions.
The repair and functional reconstruction of large segmental bone defects in load-bearing regions are extremely difficult, mainly because the body's capacity to recruit endogenous functional ions such as Ca2+, Cu2+, and Mg2+ to facilitate mineralization and vascularization is compromised. Herein, inspired by the bioelec...