Author

Jia-Ke Xu

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Open access Aug 2026

Identification of a novel small-molecule modulator targeting SNX10 to inhibit osteoclastic bone resorption.

Current antiresorptive therapies reduce bone loss by eliminating osteoclasts or inhibiting their formation. However, these approaches could disrupt osteoclast-osteoblast communication and cause serious complications with long-term usage. There is a need for developing new therapies that selectively inhibit resorptive f...

Yihe Li, Qi-Hang Wu, Shengnan Qin et al. · Journal of Bone and Mineral... · 0 citations

Sep 2026

Cyclovirobuxine Prevents Osteoclastogenesis and Estrogen Deficiency-Induced Bone Loss by Inhibiting ROS Generation via the PI3K/AKT/FOXO1 Pathway

The results suggest that CVB suppresses osteoclastogenesis and their resorptive function through modulation of MAPK and PI3K/AKT/FOXO1 pathways and by enhancing antioxidant defense, which has potential therapeutic value for antiosteoporosis treatment.

Qiu-Fei Li, Na Hai, Jin-Deng Liao et al. · Journal of Agricultural and... · 0 citations

Open access Aug 2026

Eriodictyol regulates LDHB to trigger mitophagy-mediated NLRP3 inflammasome inactivation as a therapeutic strategy for bone loss.

It is confirmed that ERI maintains bone homeostasis by regulating PINK1/Parkin-mediated mitophagy and suppressing NLRP3 inflammasome activation, which may provide a novel natural candidate for the treatment of bone loss-related diseases.

Yi-Yuan Wang, Wen Pu, Yuangang Su et al. · Pharmacological Research · 0 citations