Author

Jia-le Zhu

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Open access Aug 2026

Histone lactylation encodes innate immune memory in atherosclerosis: a hypothesis of epigenetic bookmarking for residual inflammatory risk

It is proposed that cardiovascular risk factors stabilize HIF-1α, which drives glycolytic reprogramming and sustained lactate production and provides a mechanistic explanation for residual inflammatory risk, the observation that elevated cardiovascular events persist despite optimal lipid-lowering therapy.

Hao-Bo Yang, Yonghui Zhang, Yunfeng Yu et al. · Clinical Epigenetics · 0 citations

Open access Aug 2026

Single-Cell and Machine Learning Analyses Identify a PFKFB3-Centered Regulatory Network and Potential Salidroside Interaction in Coronary Heart Disease

The findings support PFKFB3 as a potential biomarker and mechanistic hub and suggest that salidroside may modulate its activity and provide a multi-layered framework connecting glycolytic remodeling, inflammatory transcriptional activity, and intercellular signaling in CHD.

Hao-Bo Yang, Yonghui Zhang, Yun-Feng Yu et al. · International Journal of Mol... · 0 citations

Review Open access Aug 2026

The NRF2 signaling pathway in hepatocellular carcinoma: dual roles, epigenetic reprogramming, and therapeutic opportunities in metabolic vulnerability

NRF2-related metabolic pathways and redox defense systems exhibit potential metabolically targetable vulnerabilities, providing a theoretical basis for combined induction of ferrocytosis and metabolic intervention in HCC.

Yue Wang, Lingwei Gao, Hao-Bo Yang et al. · Frontiers in Oncology · 0 citations