O-GlcNAcylation is an important post-translational modification that regulates numerous cellular processes, yet tools enabling selective removal of O-GlcNAc from individual proteins via endogenous O-GlcNAcase (OGA) in living cells remain limited. Here, we report De-O-GlcNAcylation-targeting chimeras (DOGTACs), a chemic...
An O-GlcNAcylation-targeting Chimera (OGTAC) is developed that recruits O-GlcNAc transferase (OGT) to the oncogenic transcription factor c-Myc, enabling targeted O-GlcNAcylation in living cells without globally perturbing cellular O-GlcNAcylation.
Tong-Yang Xu, Zhi-Hao Guo, K. S. Khan et al.· Cell Chemical Biology· 2 citations
Cryo-EM structures of historical and contemporary AFM-associated EV-D68 strains, together with their complexes bound to the third extracellular loop of MFSD6, reveal a glycan-mediated dual-lock mechanism that may enhance receptor specificity, prevent premature uncoating, and ensure productive infection only upon engage...
