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Open access Sep 2026

The C-reactive protein–albumin–lymphocyte index is associated with ventricular functional improvement and long-term outcomes after cardiac resynchronization therapy

Background and aims Inflammation, malnutrition, and immune dysfunction are closely linked to adverse outcomes in heart failure. The C-reactive protein–albumin–lymphocyte (CALLY) index integrates these biological domains, but its clinical relevance in patients undergoing cardiac resynchronization therapy (CRT) remains i...

Run Zhang, Qing-Qing Duan, Xin Lv et al. · 0 citations
Sep 2026

Dapagliflozin Ameliorates Pulmonary Arterial Hypertension-Induced Right Heart Failure via Ketone Body Metabolism and Mitochondrial Function Enhancement.

BACKGROUND Pulmonary arterial hypertension (PAH)-induced right ventricular (RV) failure increases reliance on ketones. The efficacy of SGLT2 inhibitors, known to modulate ketone metabolism, in this context remains unclear. METHODS A PAH model was established in Sprague-Dawley rats via a single intraperitoneal injecti...

Wen-Dong Xu, Jia Liu, Long-Long Yan et al. · 0 citations

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