PURPOSE
Na+/H+ exchanger 1 (NHE1), encoded by SLC9A1, is a widely expressed plasma membrane transporter that exchanges intracellular H⁺ for extracellular Na⁺ and plays a central role in intracellular pH regulation. Beyond ion transport, NHE1 also functions as a membrane-associated regulatory platform involved in cell v...
Chang-Jian He, Tian He, Rui-Qing Tian et al.· Digestive Diseases and Scien...· 0 citations
Inflammatory bowel diseases (IBD) represent a spectrum of chronic gastrointestinal disorders fueled by a complex multifactorial interplay, where mitochondrial dysfunction has emerged as a critical contributor. The SLC25 family of mitochondrial transporters mediates the exchange of essential metabolites across the mitoc...
Juan Xu, Zan Zuo, Pei-Lin Wang et al.· Frontiers in Immunology· 0 citations
This work unveils POLRMT as a metabolic gatekeeper that licenses CSC plasticity through KDM6B-α-KG/H3K27me3-mediated chromatin remodeling, proposing the mitochondrial transcription machinery as a therapeutic target for dismantling the CSC hierarchy in CRC.
Lei Tang, Siheng Nie, Jia-Long Qi et al.· Cell Death and Differentiati...· 0 citations
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