Review
Open access
Oct 2026
Gut microbiota-driven imbalance of the gut-brain-immune homeostatic network in constipation: Pathogenic mechanisms and evolving therapeutic prospects
Summary Chronic constipation (CC) is increasingly recognized as a systems-level disorder that cannot be explained by impaired intestinal motility alone. Here, we integrate evidence from clinical cohorts, animal models, and mechanistic studies to examine how gut microbial dysbiosis and altered microbial metabolites pert...
Jia-Ning Zhu, Bin-Bin Zeng, Wen-Xu Zhu et al.
· iScience · 0 citations