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Author

Jia-Min Geng

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Open access Aug 2026

Multi-omics integration identifies HSPA4 as a therapeutic target and reveals DON-induced endoplasmic reticulum stress in bladder cancer

The significance of HSPA4 as a potential therapeutic target in bladder cancer is highlighted and the compound 6-Diazo-5-oxo-L-norleucine was predicted and subsequently validated to bind stably to HSPA4, demonstrating that DON exerts antitumor effects by targeting HSPA4 and activating the ERS pathway.

Jin Zhou, Jia-Min Geng, Han-Kai Qiu et al. · 0 citations

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