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Author

Jiaqi Hu

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Open access Sep 2026

Identifying shared polygenic risk across cancers

Background Shared genetic susceptibility across cancers has been reported but is generally modest at the genome-wide level. Whether such shared polygenic risk exhibits structured convergence at regional or functional levels remains unclear. We investigated shared genetic risk across cancers by integrating local genetic...

Jia-Qi Hu, Maiyier Muheyati, Le-Qi Xu et al. · 0 citations
Open access Jul 2026

Cell-type-specific polygenic risk scores reveal adipocyte-related interactions with lipids in coronary artery disease

Cell-type-specific decomposition of genome-wide PRSs for CAD identified biologically distinct lipid interactions that were not captured by the genome-wide PRS, highlighting the potential of cell-type-informed PRSs to improve the biological interpretation of PRSs and provide insights into the heterogeneous mechanisms un...

Jia-Qi Hu, Le-Qi Xu, Tian-Yu Liu et al. · 0 citations

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