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Jia-Qi Lin

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Preprint Aug 2026

Reliable Neural Collapse Approximation for Open-World Test-Time Adaptation

Test-Time Adaptation (TTA) methods aim to bridge the domain gap between the source and target domains. However, traditional TTA methods become ineffective when the label distribution shift occurs, a challenge commonly referred to as an open-world scenario. In this paper, we introduce a new method named Reliable Neural Collapse approximation (ReNC) for Open-World Test-Time Adaptation (OWTTA). Specifically, we leverage neural collapse as a structural prior for reliable target-domain adaptation. Guided by this prior, we justify that the pre-trained classifier weights can serve as the prototypes of the source domain. By measuring the similarity between samples and prototypes, we filter out the Out-Of-Distribution~(OOD) samples for reliable updates. Furthermore, we propose a neural collapse approximation mechanism to refine these prototypes, ensuring they can gradually adapt to the target domain while maintaining the neural collapse structure. Extensive experiments on several open-world benchmarks demonstrate the superiority of the proposed method. Our empirical analysis suggests that ReNC better preserves NC-related properties in the target domain, providing useful evidence for explaining reliable OWTTA and offering new insights for model design. Code is available at https://github.com/JiaqiLin-AI/ReNC.

Jia-Qi Lin, Yuangang Pan, Changran Wang et al. · 0 citations
Preprint Aug 2026

PETA:Parameter-Efficient Test-Time Adaptation for Virtual Screening

This work forms the specialization of pretrained virtual screening models to individual pockets as a test-time adaptation problem and proposes PETA, a parameter-efficient framework that directly adapts pretrained model at test time and outperforms both pretrained and fully retrained baselines while updating only the LayerNorm parameters.

Jia-Qi Lin, Yinghua Yao, Changran Wang et al. · 0 citations