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Jia-Qi Wang

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Open access Sep 2026

RFOptimization: Guiding Design Optimization with All-Atom Structure Prediction

RFO formulates binder improvement as a residue-wise mutational search problem, sampling candidate substitutions alternately based on gradient-guided sequence optimization using all-atom structure prediction models and a cycling-based sequence redesign strategy that alternates structure generation with an orthogonal pre...

Odin Zhang, Jia-Qi Wang, T. Thompson et al. · 0 citations

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