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Author

Jia-Qi Weng

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Open access Oct 2026

Acid-responsive nanoparticles with microneedles for anti‑inflammatory sonodynamic therapy of gouty arthritis

Abstract The pathological microenvironment of acute gouty arthritis (AGA) features local tissue acidification and the release of a storm of pro-inflammatory cytokines. To address this dual challenge, we engineered an acid-responsive curcumin-loaded nanoparticles microneedle system (Cur-PNPs@MN) that delivers curcumin w...

Jia-Qi Weng, Li-Li Feng, Bing-Hui Xie et al. · 0 citations
Sep 2026

Personalized curved-backing microneedles with amphotericin B-loaded nanoparticles for fungal keratitis treatment.

A finite element simulation-assisted strategy to fabricate personalized curved-backing microneedles with a curvature-matched backing that ensures conformal surface contact, controlled penetration depth, and uniform drug distribution, effectively overcoming the limitations of conventional MNs is reported.

Shu-Lin Shen, Li-Ting Wang, Yun Li et al. · 0 citations

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