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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Jia-Qiang Wang

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Open access Oct 2026

SEC Mediates m6A Deposition and Transcription Pause Release to Drive Cell Identity Transition

ABSTRACT Background: Induced pluripotent stem cell (iPSC) reprogramming and embryonic stem cell (ESC) differentiation represent opposite models of cell identity transition, yet their regulatory mechanisms remain incompletely understood. Here, we identify the Super Elongation Complex (SEC), the most pivotal regulators o...

Zhi-Jing Zhang, Jing-Yi Xu, Yong-Hong Wu et al. · 0 citations
Open access Aug 2026

TUG1 supports mouse two-cell-stage development and ZGA-associated transcription through MAPK8 signaling

It is demonstrated that TUG1, which is highly expressed in tumors, regulates early embryonic development in mice and is transformed from a cancer-specific effector to a critical regulator of the ZGA, raising the possibility that related regulatory principles may operate in other biological contexts.

Jian-Wu Wang, Guang Yang, Qingbo Yang et al. · 0 citations

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