Review
Open access
Sep 2026
Tertiary lymphoid structures in cancer: their development, composition, clinical prognosis, and the drivers of the anti-tumor responses
Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates formed under chronic inflammatory tumor microenvironments. Clinical cohorts across solid cancers demonstrate that mature TLS with intact germinal centers serve as independent favorable prognostic biomarkers and predict superior responses to immune check...
Zhi-Chao Dou, Yu-Chao Shi, Kun Meng et al.
· Molecular Biomedicine · 0 citations