Aug 2026
Fragment-based discovery of novel Baicalein derivatives as triple-target 3CLpro/PLpro/RdRp inhibitors against SARS-CoV-2.
The rapid evolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the emergence of drug resistance necessitate the development of multi-target antiviral therapeutics. This study aimed to computationally design a novel triple-target inhibitor derived from the natural flavonoid Baicalein, targeting...
Di Han, Hong-Kun Yang, Yi-Fan Wang et al.
· Bioorganic chemistry (Print) · 0 citations