Dichloromethane Extract Is Responsible for the Evodiae Fructus induced Hepatotoxicity via PI3K-AKT/MAPK/p53/NF-κB Signaling Pathways through Integrated Network Pharmacology, Proteomic and Transcriptomic Analyses.
ETHNOPHARMACOLOGICAL RELEVANCE Tetradium ruticarpum (A.Juss.) T.G. Hartley (syn. Evodia rutaecarpa (Juss.) Benth., Rutaceae) , known as Wuzhuyu in Chinese and Evodiae Fructus (EF) in English, is a traditional Chinese medicine (TCM) with a history of over two thousand years. It was first documented in Shen Nong's Herbal...