Kidney disorders have become a prevalent global public health crisis, accompanied by soaring morbidity and insufficient therapeutic regimens in clinical practice. Celastrol, a biologically active pentacyclic triterpenoid isolated from
Tripterygium wilfordii
, is well documented to exert powerful anti-inflammatory,...
Yi-Ning Chen, Meng-Dan Lu, Ting Xu et al.· Asian Pacific Journal of Tro...· 0 citations
Results indicate that GQYS treats DN mainly through the anti-inflammatory effects, providing a potential theoretical basis for its clinical application and demonstrating the reliability of the integrative strategy.
Jia-Wei Cao, Meng-Dan Lu, Peng Bi et al.· RSC Advances· 0 citations
A spatiotemporal framework is proposed that extends beyond previous disease- or pathway-centered perspectives by integrating the timing and cellular context of S100A8/A9 signaling to establish stage-specific biomarker and therapeutic strategies targeting S100A8/A9 in precision nephrology.
Meng-Ge Zhu, Meng-Dan Lu, Jia-Wei Cao et al.· Journal of Inflammation Rese...· 0 citations
Clinical and animal experiments have shown that Gui-qi-yi-shen (GQYS) granules, a traditional Chinese medicine formula, exhibited considerable therapeutic efficacy in the treatment of diabetic nephropathy (DN). However, the underlying pharmacological mechanisms remain unknown. To address this, we investigated the poten...
Jiawei Cao, Meng-Dan Lu, Peng Bi et al.· RSC Advances· 0 citations
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