Jia-Wei Chen

CUDC-907 attenuates pulmonary fibrosis by reversing HDAC1-mediated SMAD4 deacetylation at lysine 45

Pulmonary fibrosis is characterized by the persistent activation of fibroblasts into myofibroblasts, a process largely driven by TGF-β/SMAD signaling. Acetylation has emerged as a fundamental regulatory mechanism in cellular homeostasis and tissue fibrosis, yet whether and how the acetylation of core SMAD transcription...