Author

Jia-Wei Fu

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Open access Jan 2026

Targeted Delivery of Triptolide Via Folate-Functionalized Pluronic Micelles Enhances Anti-Melanoma Activity by Inducing Reactive Oxygen Species Accumulation.

Melanoma remains a highly lethal malignancy, often associated with limited therapeutic efficacy and substantial systemic toxicity caused by conventional chemotherapy. Triptolide (TP) exhibits potent antitumor activity, but its clinical application is limited by poor aqueous solubility and a narrow therapeutic window. I...

Gen-Ying Zhuang, Yan-Li Chen, Xiu-Li Gao et al. · BioMed Research Internationa... · 0 citations

Aug 2026

circFBXO7 promotes ferroptosis in vascular endothelial cells exposed to high glucose through enhancing proteasomal degradation of TFCP2.

Findings identify a novel circFBXO7-TFCP2 regulatory axis linking metabolic stress to endothelial ferroptosis, providing new insight into the molecular basis of diabetic vascular dysfunction.

Chen-Yang Qiu, Tian-Chi Chen, Zhengyuan Fang et al. · Vascular pharmacology · 0 citations