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Author

Jia-Wen Ding

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Open access Sep 2026

Targeting Iron Regulatory Protein 2 in Tumor-associated Macrophages Activates Antitumor Immunity in NSCLC via Modulating SphK1-PD-L1 Axis

IRP2-dependent maintenance of the immunosuppressive TAM phenotype as a promising therapeutic target in NSCLC is identified, finding that IRP2 skewed TAMs toward an immunosuppressive state that promoted tumor cell proliferation and migration, and limited apoptosis.

Jia-Wen Ding, Qin-Pei Cheng, Chen Cheng et al. · 0 citations

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