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Jia-Xin Guo

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Jul 2026

Biosynthesis of Fluorinated Aromatic Polyketides Through Directed Evolution of Fused Type III Polyketide Synthase.

A series of combinational optimization strategies, including metabolic regulations, double protein fusion, and directed evolution of the rate-limiting enzymes, were conducted to improve the production of fluoro-aromatic polyketides, thus enhancing the titers to >200 mg/L from an initial ∼10 mg/L.

Ze-Long Mei, Jia-Xin Guo, Zhou-Tong Sun et al. · 0 citations

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