Open access
Oct 2026
CMTM6 regulates hematopoietic stem cell homeostasis through modulating IFNRs-STAT1-KLF4 signaling axis.
INTRODUCTION CMTM6 is known to stabilize PD-L1 on cancer cells, facilitating immune evasion, but its role in normal hematopoiesis remains unexplored. Hematopoietic stem cell (HSC) homeostasis is tightly regulated by interferon (IFN) signaling, yet the mechanisms controlling IFN receptor stability are unclear. OBJECTI...
Huan-Di Qiu, Wei He, Yun-Lu Feng et al.
· Journal of Advanced Research · 0 citations