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Jiaxu Chen

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Review Open access Sep 2026

Magnetic Resonance Imaging in Cerebral Small Vessel Disease‐Related Depression: From Visual Scoring to Artificial Intelligence

ABSTRACT Background Cerebral small vessel disease (CSVD) is the key pathological basis of vascular depression. The precise identification of its neuroimaging markers is of core value for early diagnosis, elucidation of its pathological mechanism, and individualized treatment. Recent advances in magnetic resonance imagi...

Chao-Fang Lei, Jia-Xu Chen, Yi-Long Wang · 0 citations
Review Open access Oct 2026

From bench to beside: luteolin's therapeutic promise in neurological disorders.

Luteolin (3',4',5,7-tetrahydroxyflavone) is a naturally occurring flavonoid found in diverse plant families, including Apiaceae, Brassicaceae and Lamiaceae, and is a major bioactive component of Chinese medicines such as Chrysanthemum morifolium and Perilla frutescens. It possesses antidepressant, anti-inflammatory, an...

Wen-Jun Zhu, Nai-Jun Yuan, Man-Shi Tang et al. · 0 citations
Aug 2026

Multimodal MRI signatures and concurrent myelin remodeling alterations in the anterior cingulate cortex correlate with the antidepressant-like effects of 18β-glycyrrhetinic acid in CSDS mice.

BACKGROUND The anterior cingulate cortex (ACC) regulates emotion, and its dysfunction is associated with depression. 18β-glycyrrhetinic acid (18β-GA) exerts robust antidepressant effects; however, its roles in neural circuit remodeling of the ACC and underlying molecular mechanisms remain unclear. This study investigat...

Yongxin Li, Yun Ran, Wen Ning et al. · 0 citations

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