Jia-Xuan Chen

Tunable and self-reporting esterase-activated cyanide prodrugs exert cytoprotective effects

Hydrogen cyanide (HCN) is increasingly recognized as a mammalian gasotransmitter with biphasic biological effects, but its study is limited by the lack of controllable delivery tools. Here we report esterase-activated, self-reporting cyanide donors with tunable release kinetics and fluorogenic readout. Upon esterase ac...