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Jia-Yan Wu

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Open access Sep 2026

CTLA-4 haploinsufficiency leads to late-onset autoimmune pathology in mice

Summary In humans, the loss of function in a single copy of the CTLA4 gene leads to an immune disorder characterized by a spectrum of immunodeficient and autoimmune manifestations. To investigate the pathogenicity of CTLA-4 haploinsufficiency, we utilized a heterozygous mouse model carrying a patient-derived Y139C muta...

Qing-Man Li, Zhi-Shan Zhao, Yi-Chi Zhang et al. · 0 citations

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