Review
Aug 2026
Selective PARP1 inhibitors (2021–2025): patent landscape, structural evolution, and future therapeutic opportunities
Current patents indicate that adenine-pocket engagement, linker optimization, conformational control, and scaffold innovation are central to achieving high PARP1 selectivity and represent important directions for future intellectual property development.
Ji-Long Duan, Yan-Jing Duan, Dong-Ling Gu et al.
· Expert Opinion on Therapeuti... · 0 citations