Author

Jia-Yin Yue

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Sep 2026

Investigating the anti-TNBC potential of new quinazoline-based PAK4 inhibitors: design, synthesis and biological evaluation.

Results validate 11j as a promising lead for TNBC therapy, especially in combination with EGFR-targeted agents.

Shuang Hao, Yi-Fan Niu, Meng Si et al. · European journal of medicina... · 0 citations

Open access Jul 2026

Proposed Allosteric Inhibition of Cyclin-Dependent Kinase 4 by a Proline-Derived Acylsemicarbazide Compound with Antiproliferative Activity in Breast Cancer Cells

Background: Cyclin-dependent kinase 4 (CDK4) is a key regulator of cell-cycle progression and an established therapeutic target for breast cancer. Although the unique architecture of its ATP-binding site has enabled the development of highly selective inhibitors, the emergence of acquired resistance highlights the need...

Xu Huang, Qing-yang Nian, Xi-Zhe Sun et al. · Pharmaceuticals · 0 citations