Author

Jia-Yuan Chen

2 papers indexed here

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Sep 2026

Programming 2,3-butanediol biosynthesis in Saccharomyces cerevisiae with AI-optimized dual-optogenetic switches.

Microbial cell factories promise sustainable biomanufacturing, yet balancing cellular growth and product synthesis remains a fundamental productivity bottleneck. While traditional static metabolic engineering fails to precisely orchestrate metabolic flux across temporal and spatial dimensions, optogenetic approaches of...

Sai-Nan Yang, Ren-Mei Liu, De-Chong Ou et al. · Bioresource Technology · 0 citations

#artificial intelligence Preprint Sep 2026

AmbiModBench: Benchmarking Gene Perturbation Prediction Beyond Shared Responses

Predicting cellular responses to genetic perturbations helps prioritize experiments in single-cell genomics, where exhaustive measurement is infeasible. While computational models increasingly predict these responses, three evaluation deficiencies obscure what their scores demonstrate. First, absolute metrics cannot se...

Si-Kai Huang, Zhi-Wen Yang, Kai Yu et al. · 0 citations