Open access
Aug 2026
Perturb-ME: Scalable mechanism discovery from phenotype-enriched genome-wide screens
Perturb-ME, along with agentic interpretation, provide a scalable framework for comprehensive functional discovery from phenotype-enriched genetic screens and combines genome-scale CRISPR screening, phenotype-based enrichment and multimodal single-cell profiling.
Han-Chen Wang, Jiacheng Gu, Chris J. Frangieh et al.
· bioRxiv · 0 citations