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[This corrects the article DOI: 10.1016/j.synbio.2026.05.015.].
α-Ketoglutarate (α-KG)-dependent nonheme iron enzymes catalyze a diverse array of oxidative transformations essential for natural product biosynthesis. However, the mechanism by which α-KG/Fe-dependent halogenases achieve selective halogenation while circumventing the thermodynamically favored hydroxylation pathway rem...
It is demonstrated that the cytochrome P450 monooxygenase CyaI catalyzes an oxidation reaction through a zwitterionic intermediate and facilitates a subsequent unusual C→N acetyl migration, which triggers a spontaneous intramolecular cyclization to forge the imidazolidin-4-one ring during 1 biosynthesis.
A small-sample, accelerated evolution strategy that integrates focused rational iterative site-specific mutagenesis (FRISM) with the EVOLVEpro model is reported, providing a robust, "lightweight" machine learning framework for the rapid development of new-to-nature photoenzymatic transformations.
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