Clofoctol-derived amphiphilic peptidomimetics exhibit broadened antimicrobial activity via multiple contributing mechanisms.
INTRODUCTION Antimicrobial resistance (AMR) poses an escalating global health threat, yet the antibiotic discovery pipeline has stagnated over recent decades. Multi-mechanistic antibacterial action may offer a promising strategy to address this challenge. OBJECTIVES This study aimed to use clofoctol, a clinically use...