Aug 2026
Tet1-mediated 5-hydroxymethylcytosine alterations in the olfactory bulb are associated with aberrant neurogenesis and PI3K-Akt signaling in response to CIH.
Tet1 knockdown in the OB partially normalized PI3K-Akt signaling, was associated with improved neurogenesis markers, and alleviated CIH-induced olfactory dysfunction, suggesting that Tet1 may serve as a potential therapeutic target for CIH-related sensory impairment.
Yaru Kong, Yuwei Qi, Jiajia Dong et al.
· Experimental Neurology · 0 citations