Jiajun Dong

Discovery of Non-Inhibitory Macrocyclic Ligands for Protein Tyrosine Phosphatase 1B Using a Function-Based, Iterative Screening Strategy

Chemically induced proximity is a powerful modality for manipulating protein function. Most of the effort in this field has focused on targeted protein degradation but recruitment of other types of post-translational modification enzymes to a target protein is also of interest. To construct such reagents, one would ide...