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Author

Jiali Huang

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Jul 2026

Panax quinquefolius saponins promote remyelination via orchestrating HMGCS1-NPC1-MAL-mediated lipid metabolism and rebalancing JAK-STAT signaling in a cuprizone-induced demyelination model.

PQS supported myelin restoration, which is correlated with a modulation of the JAK-STAT signaling pathway and HMGCS1/NPC1-associated lipid homeostasis, and may represent a potential therapeutic lead for demyelinating diseases, although mechanisms require further validation.

Jiali Huang, Le Sun, Lifeng Yue et al. · 0 citations