Jian-Bin Ruan

Structural Insights into MLKL-Mediated Necroptosis: Emerging Mechanisms.

Necroptosis is a regulated form of lytic cell death that plays important roles in inflammation, host defense, and disease. Central to this pathway is mixed lineage kinase domain-like protein (MLKL), the terminal effector responsible for membrane disruption. Upon phosphorylation by receptor-interacting protein kinase 3...