A Single-Cell Transcriptional Landscape of Emphysema: Heterogeneous Cellular Dynamics in Centrilobular, Panlobular, and Paraseptal Subtypes
These findings reveal that CLE is predominantly driven by airway-originated inflammation, PSE exhibits a fibrosis-like remodeling phenotype, and PLE represents an intermediate state of innate immune activation and matrix dysregulation, providing a single-cell resolution framework for subtype-specific therapeutic target...