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Jian-Chuan Wang

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Open access Sep 2026

Kidney fibrosis is mediated by GARP-restricted TGF-β activation in fibroblasts.

GARP-mediated release of active TGF-β is identified as a critical step in sustaining fibroblast activation during kidney fibrosis and highlight GARP as a promising therapeutic target for CKD.

Yin-Tong Chen, Wei-Wei Xu, Jie-Li Yu et al. · 0 citations
Open access Jul 2026

Antibody-mediated CAR T Platform for Targeting Tumor Cells and the Tumor Microenvironment 2301697

A dual-targeting strategy disrupted the TME-induced immune suppression, reduced collagen deposition, and boosted T cell activity, resulting in notable tumor growth inhibition and prolonged survival in both subcutaneous and orthotopic pancreatic cancer models.

Yiming Zhou, Jian-Chuan Wang, Yufei Du · 0 citations

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