Jian-Feng Lu

Integrated untargeted and targeted metabolomics identifies and validates urinary bile acid biomarkers for the diagnosis of intrahepatic cholestasis of pregnancy

Background Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-specific liver disorder and is characterized by unexplained pruritus and elevated serum bile acid levels, typically in the third trimester. Excessive bile acid accumulation is associated with maternal discomfort and adverse fetal outcom...