Breast cancer remains a major clinical challenge because of its molecular heterogeneity, therapeutic resistance, and disease recurrence. Melittin, the principal bioactive peptide of honeybee venom, exhibits antitumor activity in multiple experimental models; however, its early proteome-wide effects in breast cancer cel...
Jun-Ling Zhu, Wen-Hua Xu, He Zang et al.· Biology· 0 citations
Astral data-independent acquisition-based quantitative proteomics combined with molecular validation suggest that mitochondrial OXPHOS remodeling and redox-associated pathways may contribute to the antitumor activity of melittin.
Simple Summary Vairimorpha ceranae, a microsporidian fungus that specifically parasitizes the honeybee midgut, impairs nutrient absorption and immune function of bees, thereby posing severe threats to the health of Apis cerana cerana. Circular RNAs (circRNAs) are a class of structurally stable, degradation-resistant no...
Xue Yang, J. Lei, Yuwei Zhang et al.· Animals· 0 citations
Melittin exhibits antitumor activity in cervical cancer models, yet the long non-coding RNA (lncRNA) response and associated regulatory networks remain poorly understood. Here, strand-specific RNA-seq data from melittin-treated and untreated U14 murine cervical cancer cells were analyzed to characterize melittin-respon...
Ronghua Zhang, Haiwen Zhuo, Yun Yang et al.· bioRxiv· 0 citations
Chalkbrood disease, caused by Ascosphaera apis, threatens Apis cerana larvae. However, miRNA-mediated antifungal regulation remains poorly defined. Here, we characterized ace-miR-3759-y in A. apis-challenged A. cerana larvae. Stem-loop RT-PCR and Sanger sequencing confirmed its gut expression. Target prediction identif...
He Zang, Haimei Yue, Xiaoxue Fan et al.· Journal of Agricultural and...· 0 citations
ABSTRACT Chalkbrood, a destructive larval disease caused by the fungal pathogen Ascosphaera apis, causes substantial losses in apiculture. Although host–pathogen interactions in Apis mellifera larvae infected with A. apis have been investigated, immune defense mechanisms in the Asian honey bee Apis cerana remain unclea...
Xiaoxue Fan, Kaiyao Zhang, Yun Yang et al.· Virulence· 0 citations
Microsporidia rely extensively on host resources, yet how parasite-derived microRNAs coordinate infection remains poorly understood. Here, we investigated the function of nce-miR-12220, a miRNA identified in Nosema ceranae spores, during infection of Apis mellifera workers. Target prediction, dual-luciferase assays, an...
Rui Guo, He Zang, Wenhua Xu et al.· PLoS Pathogens· 0 citations
Findings support a negative regulatory role of novel-miR0032-5p in CAT expression and indicate that lncRNA1386.1 participates in a candidate shared miRNA-responsive regulatory relationship.
Xiaoxue Fan, Nian Fan, Kunze Li et al.· Antioxidants· 0 citations
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