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Advances in engineering microalgae for heterologous terpenoid synthesis: A review.
Terpenoids are a class of natural products widely distributed in living organisms, with isoprene as their fundamental structural unit. However, traditional plant extraction and chemical synthesis methods are often limited by low product purity, difficult separation, and complex synthetic steps, making it challenging to...
De novo synthesis of large-scale metabolic pathways for natural products and their optimization strategies.
This review systematically analyzes core strategies and cutting edge technologies for reconstructing large scale metabolic pathways in microbial cell factories using synthetic biology to address challenges such as metabolic burden, pathway imbalance, and host toxicity, ultimately paving the way for scalable and cost ef...