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Author

Jian-Hua Ju

2 papers indexed here

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Sep 2026

Identification of Cembrene Synthases Uncovers Polyphyletic Origins of 14-Membered Carbocyclic Cembranoids Biosynthesis in Corals

Ariadne is developed, an integrated platform for genome-wide targeted mining of terpene synthases from corals that establishes a new paradigm for terpene synthase discovery and substantially advances the genome mining in marine animals as well as the combinatorial biosynthesis of marine-derived natural products.

Yin-Hao Wang, Meng-Meng Yu, Zhao-Rui Jiang et al. · 0 citations
Sep 2026

An Enzyme from a Single P450 Monooxygenase Clade Orchestrates Six‑Electron Oxidation for Cyclopeptide Modification

The oxidative modification of complex natural products is critical for their biological activity. However, the enzymatic mechanisms that facilitate three-step, six-electron transfer reactions, such as the conversion of a methyl group to a carboxylic acid, on cyclopeptide scaffolds remain poorly understood. This study...

Ming Peng, Qiao-Ling Wu, Ying-Ying Chen et al. · 0 citations

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