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Author

Jian-Hua Wu

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Sep 2026

NEDD4L-mediated ALYREF ubiquitination degradation suppresses RUBCNL expression to impair autophagy and promote lipogenesis in alcoholic hepatic fibrosis.

BACKGROUND Alcoholic hepatic fibrosis (AHF) is a progressive disease with limited therapeutic targets. This study investigated the role and mechanism of RUBCNL in AHF pathogenesis. METHODS The AHF mouse model was established using a chronic-plus-binge ethanol feeding protocol combined with CCl4 injection. Acetaldehyd...

Xian-Liang Hu, Jian-Hua Wu, Yu-Xin Huang et al. · 0 citations

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