Jian-Hui Chen

Brain control of hepatic bile acid homeostasis through Bdnf exon I-positive neurons in the paraventricular hypothalamus

Bile acids (BAs) are produced in the liver and regulate whole-body cholesterol balance. Whether and how the brain regulates liver function, including BA homeostasis, remains largely unexplored. Here we show that a subpopulation of liver-connected Bdnf-e1-expressing hypothalamic neurons regulates BA metabolism in the li...