Author

Jian-Hui Wang

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Sep 2026

Mapping cell-type- and age-dependent neuronal vulnerability through genome-wide in vivo CRISPRi screens in the mouse brain.

Current brain atlases are largely descriptive, cataloging correlative molecular snapshots such as gene expression signatures yet offering limited functional insight. Here, we develop a scalable, cell-type-resolved in vivo CRISPR interference (CRISPRi) platform enabling systematic gene function profiling in the mouse br...

Risheng Lin, Ze-Ting Ke, Jian-Hui Wang et al. · Neuron · 0 citations

Open access Jul 2026

A pooled CRISPR-based neuronal activity screen links TMEM50A-dependent MVB function to synaptic integrity and remote memory.

A high-throughput functional genomics platform that couples the calcium-integrating sensor CaMPARI2 with CRISPRi screening in human iPSC-derived neurons is established and reveals a critical role for TMEM50A-dependent MVB function in maintaining synaptic integrity and behavior.

Jian-Hui Wang, Meiqi Liu, Yi-Ming Chen et al. · Cell Reports · 0 citations